What action must be taken if a pharmacist receives a prescription with unclear directions?

If a pharmacist receives a prescription with unclear directions, the appropriate action is to contact the prescriber for clarification. This is essential for ensuring patient safety and the accurate dispensing of medication. The directions on a prescription provide critical information regarding dosage, frequency, and administration, which are vital for the effective treatment of the patient. Ambiguities in these directions can lead to medication errors, potentially causing harm to the patient.

By reaching out to the prescriber, the pharmacist can confirm the intended instructions, making it possible to fill the prescription as accurately as possible. This practice not only upholds professional standards but also aligns with the principles of responsible pharmacy practice which emphasize the importance of clear communication in healthcare.

The other options do not prioritize patient safety or professional responsibility. Filling the prescription without clarification could lead to serious consequences if the directions are misunderstood. Refusing to fill the prescription or documenting the inability to fill without attempting to seek clarification does not advance patient care and could result in delays in necessary treatment.